Scientist, New Targets

Company: Avidity Biosciences, Inc.
Location: San Diego
Posted on: March 30, 2025

Job Description:

Job Title: Scientist, New TargetsLocation: San Diego, CAPosition type: Full timeFLSA: ExemptDepartment: BiologyFinance ID: 1201-V68159-BFProfoundly Improve People's Lives by Revolutionizing the Delivery of RNA TherapeuticsAt Avidity Biosciences, we are passionate about the impact of every employee in realizing our vision of improving people's lives by delivering a new class of RNA therapeutics. Avidity is revolutionizing the field of RNA with its proprietary AOCs, which are designed to combine the specificity of monoclonal antibodies with the precision of oligonucleotide therapies to address targets and diseases previously unreachable with existing RNA therapies. If you are a committed, solution-oriented thinker, join us in making a difference and become part of our growing culture that is integrated, collaborative, agile and focused on the needs of patients.Avidity Biosciences, Inc.'s mission is to profoundly improve people's lives by delivering a new class of RNA therapeutics - Antibody Oligonucleotide Conjugates (AOCs). Utilizing its proprietary AOC platform, Avidity demonstrated the first-ever successful targeted delivery of RNA into muscle and is leading the field with clinical development programs for three rare muscle diseases: myotonic dystrophy type 1 (DM1), Duchenne muscular dystrophy (DMD) and facioscapulohumeral muscular dystrophy (FSHD). Avidity is broadening the reach of AOCs with its advancing and expanding pipeline, including programs in cardiology and immunology through internal discovery efforts and key partnerships. Avidity is headquartered in San Diego, CA. For more information about our AOC platform, clinical development pipeline, and people, please visit and engage with us on and .The OpportunityAvidity is seeking a highly motivated Ph.D.-level scientist with a background in biomedical sciences to join our Discovery Biology team, who can contribute to and help drive the expansion of our AOC platform. A successful candidate will play a crucial role in leading project teams both internally and externally, collaborating with partners to deliver project goals. The candidate will utilize a wide array of experimental techniques inherent to cellular biology and biochemistry across several in vitro and in vivo models and will be expected to produce exceptional results in a laboratory setting. Additionally, the candidate will have experience with receptors in the field of neuromuscular research.What You Will Contribute

• Drive forward in vitro and in vivo research projects aimed at expanding Avidity's AOC platform technology.
• Identify and implement strategies for specific oligo delivery into neuromuscular and other tissues.
• Design and perform experimental assays in support of ongoing research efforts in Discovery Biology.
• Work with and manage collaborations with CROs to achieve program goals.
• Establish and implement new techniques that can positively impact our platform technology.
• Collaborate with other members of the Discovery Biology team as well as other teams throughout Avidity to deliver on corporate goals.
• Demonstrate critical thinking skills and the ability to clearly present results in a publication-ready format.What We Seek
• A Ph.D. degree in Biomedical Sciences with a minimum of 2+ years of industry experience.
• Deep understanding of receptor biology in the neuromuscular space.
• Demonstrated success in research project completion, preferably by having multiple publications in peer-reviewed journals.
• Excels in techniques critical for molecular and cellular biology experiments, including RNA isolation, quantitative PCR, immunohistochemistry, and western blotting.
• Expertise in scRNAseq, spatial transcriptomics, RNAscope, and/or proteomics is a plus.
• Adept at mammalian cell culture, including caring for and passaging primary and immortalized cell lines and siRNA transfections. Experience with maintaining/differentiating stem cell lines is a plus.
• Strong organizational skills, including the ability to conduct several projects simultaneously.
• Proficient at establishing new assays to drive projects forward.
• Excellent computer and data analysis skills, specifically with Microsoft Office Suite and GraphPad Prism.
• Clear and professional written and verbal communication, including the ability to present research findings in a large group setting.
• Enthusiastic attitude to work independently and in a project team-oriented environment.Physical Requirements/Demands:
• Repeating motions that may include the fingers, wrists, hands, and/or legs.
• Remaining in a stationary position, often standing or sitting for prolonged periods.
• Adjusting or moving objects up to 50 pounds.
• Operating machinery and laboratory equipment.Environmental Conditions:
• Low temperatures.
• Noisy environments.
• Exposure to general laboratory environment conditions.
• Exposure to general office environment conditions.What We Will Provide To You
• The base salary range for this role is $118,750 - $131,250. The final compensation will be commensurate with factors such as relevant experience, skill set, internal equity, and market conditions.
• Avidity offers competitive compensation and benefits, which include the opportunity for annual and spot bonuses, stock options, and RSUs, as well as a 401(k) with an employer match. In addition, the comprehensive wellness program includes coverage for medical, dental, vision, and long-term disability (LTD), as well as four weeks of paid time off.
• A commitment to learning and development, which includes a variety of internally developed programming for Avidity employees, job-specific training opportunities offered by industry, and an education reimbursement program.Avidity Biosciences10578 Science Center Dr. Suite 125San Diego, CA 92121O: 858-401-7900F: 858-401-7901#LI-DNI
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Keywords: Avidity Biosciences, Inc., San Diego , Scientist, New Targets, Other , San Diego, California