Scientist, Therapeutic Discovery

Company: Exokeryx
Location: San Diego
Posted on: April 1, 2025

Job Description:

Janux is seeking a highly motivated Scientist with demonstrated skills in standard assay execution related to multi-specific antibody discovery and screening methods. The candidate will participate in hands-on pre-clinical drug discovery and development programs with a focus on quantitatively characterizing antibody binding, biophysical and functional characteristics. The candidate will characterize and develop large molecules as a key member of the drug discovery team. The successful candidate will have extensive hands-on experience with standard immunological and cancer biology techniques (ELISA, Octet BLI or biacore SPR, cell-based reporter and functional assays, flow cytometry and others).This position is hands-on and requires the effective communication and documentation of results that enable the advancement of novel research molecules toward development candidates. Ideal applicants will be collaborative and team-oriented, possess excellent communication and organizational skills, and carry a strong commitment to excellence.Duties and Responsibilities:

• Perform quantitative ELISA-based characterization of peptides and antibody molecules (96 and 384 well)
• Conduct basic protein analysis: SDS-PAGE, Western blot and protein quantification
• Perform and analyze protein-protein interaction and kinetic assays (BLI, Octet)
• Perform mammalian cell culture and cell banking
• Conduct and help develop new cell-based in vitro assays: cell-mediated cytotoxicity, functional reporter
• Conduct basic flow cytometric staining and analysis
• Complete quantitative analyses and basic interpretations of experimental data
• Produce detailed documentation of experiments within a lab notebook and electronically
• Conduct and report laboratory experiments on a daily basis
• Conduct multiple research activities in parallel
• Comfortably work with Excel and Graphpad Prism software
• Clearly communicate data to supervisor and in team meetings
• Other duties as deemed necessaryRequired Skills/Qualifications:
  • Bachelor's degree in biology, biochemistry, bioengineering, chemical biology, or related scientific discipline with 6+ years of experience in biotech/pharmaceutical industry, or Master's degree with 4+ years of experience, or PhD with 2+ years of post-doc experience.
  • Experience with flow cytometry cell staining, acquisition and analysis, ELISA, SDS-PAGE, western blot, and other standard cell based & non-cell based quantitative biochemical assays.
  • Experience bio-layer interferometry (BLI) Octet assay setup and analysis
  • Skilled in basic tissue culture techniques (cell expansion and banking) and aseptic handling of material
  • Experience with in vitro cell-based assays (Drug-induced cell-mediated cytotoxicity using real-time xCELLigence RTCA and Incucyte highly preferred, or luminescence-based)
  • Experience with flow cytometry and data analysis (FlowJo or similar software)
  • Experience completing quantitative plate based biochemical assays using various plate readers
  • Experience quantifying results in Excel and Graphpad Prism
  • Occasional weekend and/or holiday availability may be requestedSalary: $109,000 - $129,000 a yearIn addition to a competitive base salary ranging from $109,000 to $125,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies and internal equity.Job Type:Full-timeBenefits:
    • 401K
    • Medical insurance
    • Dental insurance
    • Vision insurance
    • Supplemental disability insurance plans
    • Flexible schedule
    • Life insurance
    • Flexible vacation
    • Sick time
    • Incentive stock option plan
    • Relocation assistanceSchedule:Monday to FridayWork authorization:United States (Required)Additional Compensation:Annual targeted bonus X%Work Location:On site (San Diego, CA)EQUAL OPPORTUNITY EMPLOYER:Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.
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Keywords: Exokeryx, San Diego , Scientist, Therapeutic Discovery, Other , San Diego, California