Senior Director of Structural Biology
Company: Bristol-Myers Squibb
Location: San Diego
Posted on: March 15, 2025
Job Description:
Senior Director of Structural BiologyApply locationsSan Diego -
CA - USPrinceton - NJ - UStime type Full timeposted on Posted 2
Days Agojob requisition id R1589962Working with UsChallenging.
Meaningful. Life-changing. Those aren't words that are usually
associated with a job. But working at Bristol Myers Squibb is
anything but usual. Here, uniquely interesting work happens every
day, in every department. From optimizing a production line to the
latest breakthroughs in cell therapy, this is work that transforms
the lives of patients, and the careers of those who do it. You'll
get the chance to grow and thrive through opportunities uncommon in
scale and scope, alongside high-achieving teams rich in diversity.
Take your career farther than you thought possible.Bristol Myers
Squibb recognizes the importance of balance and flexibility in our
work environment. We offer a wide variety of competitive benefits,
services and programs that provide our employees with the resources
to pursue their goals, both at work and in their personal
lives.Discovery Biotherapeutics and Leads Discovery and
Optimization (DBTx-LDO) is a multidisciplinary group of scientists
providing critical molecular discovery, structural, functional, and
mechanistic datasets to discover differentiated therapeutics. The
Structural Biology team within LDO plays a critical role in
enabling high resolution structure determination, rational design
and AI/ML enablement, across modalities (small and large molecules)
and therapeutic areas. The team works collaboratively across
adjacent functions including protein sciences, biophysics, protein
engineering, synthetic chemistry and computational chemistry for
structure-based design of novel therapeutics.We seek a Senior
Director, who will be accountable for structural biology portfolio
oversight, strategic vision setting and cross-geography (San Diego,
CA and Lawrenceville, NJ) Structural Biology team management. The
ideal candidate will be a passionate and experienced drug discovery
scientist, and proven portfolio leader, collaborator, and
innovator. This is an on-site role.Responsibilities will include,
but are not limited to, the following:
- Manage and lead state-of-the-art structural biology team of 20+
structural biologists in NJ and CA, both using x-ray
crystallography and cryo-electron microscopy (cryo-EM)
- Manage cross-site structural biology portfolio across discovery
organization for traditional small molecule, degrader, biologic and
other therapeutic modalities
- Close coordination of resources and projects and alignment with
cross-departmental protein sciences, biophysics and computation
teams to impact drug discovery programs
- Supervision, mentoring and talent development of multiple PhD
scientists and their teams Management of budgets for internal and
external data acquisition and working with CROs, key
instrumentation including cryo-EM, x-ray generator, automated
liquid dispensing and imaging, etc.
- Developing and implementing strategy for future innovation and
methodology, including cryo-EM and related methods, computational
needs and capabilities, and automation
- Effective decision making, prioritization and communication
with key stakeholders within DBTx-LDO and beyond, to drive drug
discovery across cross-functional teams
- Foster a culture of transparency, innovation, and
collaborationQualifications:
- Passionate and innovative scientist with PhD degree in
Structural Biology, Biochemistry, Protein Sciences, Chemistry or
related field, with at least 10 years experience in pharmaceutical,
biotech or other relevant drug discovery experience
- Demonstrated management and team leadership experience, with at
least 8 years managerial experience and proven ability to
collaborate effectively, act decisively and drive team
performance
- A track-record of proven accomplishments in relevant drug
discovery including publication record in peer-reviewed
journals
- Passion for learning and advancing structural biology
capabilities and drug discovery pipelines, including proactive
investigation of new techniques and capabilities, advanced
software/hardware and innovative experimental approaches
- Strong background and deep knowledge of structural biology
methods and technology, and high proficiency with protein structure
analysis
- Expertise in protein biochemistry, protein-protein
interactions, structure-function relationships and biophysical
methods strongly preferred
- Significant experience working effectively with
cross-disciplinary integrated drug discovery teams utilizing
structure-based drug design and hit-to-lead activities
- Expertise with computational methods or experience in
collaborating with computational and discovery groups would be
advantageous
- Strong interpersonal, oral and written communication skills,
highly effective in interacting with key internal and external
stakeholders, and a commitment to working collaboratively across
organizational boundaries to solve complex technical issuesUniquely
Interesting Work, Life-changing CareersWith a single vision as
inspiring as "Transforming patients' lives through science", every
BMS employee plays an integral role in work that goes far beyond
ordinary. Each of us is empowered to apply our individual talents
and unique perspectives in an inclusive culture, promoting
diversity in clinical trials, while our shared values of passion,
innovation, urgency, accountability, inclusion and integrity bring
out the highest potential of each of our colleagues.On-site
ProtocolBMS has a diverse occupancy structure that determines where
an employee is required to conduct their work. This structure
includes site-essential, site-by-design, field-based and
remote-by-design jobs. The occupancy type that you are assigned is
determined by the nature and responsibilities of your
role:Site-essential roles require 100% of shifts onsite at your
assigned facility. Site-by-design roles may be eligible for a
hybrid work model with at least 50% onsite at your assigned
facility. For these roles, onsite presence is considered an
essential job function and is critical to collaboration,
innovation, productivity, and a positive Company culture.BMS is
dedicated to ensuring that people with disabilities can excel
through a transparent recruitment process, reasonable workplace
accommodations/adjustments and ongoing support in their roles.
Applicants can request a reasonable workplace
accommodation/adjustment prior to accepting a job offer.
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Keywords: Bristol-Myers Squibb, San Diego , Senior Director of Structural Biology, Executive , San Diego, California
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